陈刚

日期:2021-03-11 访问次数:12


陈刚 教授

主要从事环境污染物对健康影响及其环境污染物的毒作用机制的研究,发表论文50余篇,其中SCI论文29篇,主持国家自然基金2项,市厅级科技项目6

招生方向

环境卫生学,  包括环境流行病学和环境毒理学

代表论文:

  1. Liu Y, Wei H , Tang JYuan J, Wu M, Yao C , Hosoi K, Yu S, Zhao X , Han Y ,  Chen G. Dysfunction of Pulmonary Epithelial Tight Junction Induced by Silicon Dioxide Nanoparticles via the ROS/ERK Pathway and Protein Degradation Chemosphere 2020 Sep;255:126954.

  2. Wu Y, Jin Y, Sun T, Zhu P, Li J, Zhang Q, Wang X, Jiang J, Chen G, Zhao X. p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation. J Nanobiotechnology. 2020 May 19;18(1):77.

  3. Zhao X, Wu Y, Li J, Li D, Jin Y, Zhu P, Liu Y, Zhuang Y, Yu S, Cao W, Wei H, Wang X, Han Y, Chen G. JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation. Toxicology. 2019 Jul 1;423:42-53.

  4. Wei H, Hu Q, Wu J, Yao C, Xu L, Xing F, Zhao X, Yu S, Wang X, Chen G. Molecular mechanism of the increased tissue uptake of trivalent inorganic arsenic in mice with type 1 diabetes mellitus. Biochem Biophys Res Commun. 2018 Oct 2;504(2):393-399.

  5. Wang Y, Chen G, Tu Q, Wu J, Qin Y, Zhu Z, Shen Y, Yan L, Han A, Xiang Q, Wang C. Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus.Biomed Res Int. 2018 Nov 27;2018:8167538.

  6. Zhao X, Jin Y, Yang L, Hou Z, Liu Y, Sun T, Pei J, Li J, Yao C, Wang X, Chen G. Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells.Toxicol Lett. 2018 Oct 15;296:73-81.

  7. Zhao X, Xing F, Cong Y, Zhuang Y, Han M, Wu Z, Yu S, Wei H, Wang X, Chen G. Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells. Int J Biochem Cell Biol. 2017 Dec;93:32-40.

  8. Mao J, Yang J, Zhang Y, Li T, Wang C, Xu L, Hu Q, Wang X, Jiang S, Nie X, Chen G. Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway. Toxicol Appl Pharmacol. 2016 Jul 15;303:79-89.

  9. Chen G, Mao J, Zhao J, Zhang Y, Li T, Wang C, Xu L, Hu Q, Wang X, Jiang S, Nie X, Wu Q.Arsenic trioxide mediates HAPI microglia inflammatory response and the secretion of inflammatory cytokine IL-6 via Akt/NF-κB signaling pathway. Regul Toxicol Pharmacol. 2016 Nov;81:480-488.

  10. Li T, Zhao J, Ge J, Yang J, Song X, Wang C, Mao J, Zhang Y, Zou Y, Liu Y, Chen G. Particulate Matter Facilitates C6 Glioma Cells Activation and the Release of Inflammatory Factors Through MAPK and JAK2/STAT3 Pathways. Neurochem Res. 2016 Aug;41(8):1969-81.


科研项目

1)国家自然基金项目 锌离子抑制细胞和组织吸收三价无机砷机制研究21277078

2)南通市科技计划项目:汽车尾气颗粒对肺血屏障紧密连接结构的影响及其分子机制研究